Research & Development
The Drug Discovery and IND Application Process: Navigating the Path to Innovation
The drug discovery process represents the initial and pivotal phase in the development of
pharmaceutical and biologic products. This intricate journey, addressing scientific rigor and
regulatory compliance, paves the way for groundbreaking medications to reach patients in need. From
the moment a potential therapeutic compound is identified to the submission of an Investigational
New Drug (IND) application to regulatory authorities, the drug discovery process unfolds as a
methodically orchestrated sequence of events.
Primary Assays high through-put, in vitro
Secondary Assays counter screen, bioavailability toxicity, metabolism, etc.
Drug Discovery and Optimization: The Inception of Innovation
Discovery commences with the identification of a promising compound that possesses
therapeutic potential. This phase, often referred to as drug discovery, involves extensive research
and screening, aiming to pinpoint compounds that exhibit the desired pharmacological activity.
Medicinal chemistry and biological screening play crucial roles in fine-tuning these compounds
to optimize their therapeutic properties.
At CureScience, the traditional drug discovery and development process has been refined to
encompass the term translational medicine and to focus more on a personalized approach to drug
discovery. Translational research plays a pivotal role in bridging the gap between fundamental
scientific breakthroughs and their practical application in clinical and community healthcare
settings. This transition from laboratory discoveries to real-world patient care, encompassing the
development of novel drugs, medical devices, and healthcare products, as well as promising
treatment modalities, is commonly referred to as the journey from the "bench-side to bedside".
Successful translational drug discovery necessitates collaboration between clinical and
pharmacological research, highlighting the critical role that academia plays in identifying potential
drug targets and in the design and development of pharmaceuticals. The translational medicine
process requires recurring interactive feedback between different disciplines for successful new
During this stage, a comprehensive understanding of the compound's pharmacological characteristics
is imperative. Scientists assess the compound's efficacy in vitro (in a laboratory setting) and in
vivo (in living organisms). They also delve into the compound's toxicological profile to identify any
potential adverse effects. This early phase is resource-intensive, with substantial investments in
research and development.